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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 1
2008 3
2009 1
2011 1
2012 1
2014 5
2015 2
2016 1
2017 3
2018 2
2019 3
2020 2
2021 4
2022 1
2023 2
2024 0

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29 results

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Page 1
Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.
Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E. Blaser MC, et al. Circulation. 2023 Aug 22;148(8):661-678. doi: 10.1161/CIRCULATIONAHA.122.063402. Epub 2023 Jul 10. Circulation. 2023. PMID: 37427430 Free article.
Pathway network analyses prioritized genes for validation in primary human carotid artery smooth muscle cells and aortic valvular interstitial cells. RESULTS: Disease progression drove significant convergence (P<0.0001) of carotid artery plaque and calcified aortic valv …
Pathway network analyses prioritized genes for validation in primary human carotid artery smooth muscle cells and aortic valvular int …
Hypoxia modulates protein phosphatase 2A through HIF-1alpha dependent and independent mechanisms in human aortic smooth muscle cells and ventricular cardiomyocytes.
Elgenaidi IS, Spiers JP. Elgenaidi IS, et al. Br J Pharmacol. 2019 Jun;176(11):1745-1763. doi: 10.1111/bph.14648. Epub 2019 Apr 22. Br J Pharmacol. 2019. PMID: 30825189 Free PMC article.
Hypoxia attenuated mRNA expression of the transcripts in a cell line- and time-dependent manner. In human aortic smooth muscle cells (HASMC) and AC16 cells, hypoxia decreased PP2Ac activity and mRNA expression without altering PP2Ac abundance. ...HIF-1alpha siRNA prevented …
Hypoxia attenuated mRNA expression of the transcripts in a cell line- and time-dependent manner. In human aortic smooth muscle cells …
PP2A negatively regulates the hypertrophic response by dephosphorylating HDAC2 S394 in the heart.
Yoon S, Kook T, Min HK, Kwon DH, Cho YK, Kim M, Shin S, Joung H, Jeong SH, Lee S, Kang G, Park Y, Kim YS, Ahn Y, McMullen JR, Gergs U, Neumann J, Kim KK, Kim J, Nam KI, Kim YK, Kook H, Eom GH. Yoon S, et al. Exp Mol Med. 2018 Jul 26;50(7):1-14. doi: 10.1038/s12276-018-0121-2. Exp Mol Med. 2018. PMID: 30050113 Free PMC article.
Transient overexpression of PPP2CA specifically regulated both the phosphorylation of HDAC2 S394 and hypertrophy-associated HDAC2 activation. ...Hypertrophic stresses, such as phenylephrine in vitro or pressure overload in vivo, caused PPP2CA to dissociate from HDAC …
Transient overexpression of PPP2CA specifically regulated both the phosphorylation of HDAC2 S394 and hypertrophy-associated HDAC2 act …
Micro-RNA 133a-3p induces repolarization abnormalities in atrial myocardium and modulates ventricular electrophysiology affecting ICa,L and Ito currents.
Kuzmin VS, Ivanova AD, Filatova TS, Pustovit KB, Kobylina AA, Atkinson AJ, Petkova M, Voronkov YI, Abramochkin DV, Dobrzynski H. Kuzmin VS, et al. Eur J Pharmacol. 2021 Oct 5;908:174369. doi: 10.1016/j.ejphar.2021.174369. Epub 2021 Jul 24. Eur J Pharmacol. 2021. PMID: 34310913 Free article.
Systemic administration of mir-133a-3p induced QT-interval prolongation. Bioinformatic analysis revealed protein phosphatase 2 (PPP2CA/B) and Kcnd3 (encoding K(v)4.3 channels generating I(to)) as the main miR-133a-3p targets in the heart. No changes in mRNA expression of C …
Systemic administration of mir-133a-3p induced QT-interval prolongation. Bioinformatic analysis revealed protein phosphatase 2 (PPP2CA …
MicroRNA-542 Promotes Mitochondrial Dysfunction and SMAD Activity and Is Elevated in Intensive Care Unit-acquired Weakness.
Garros RF, Paul R, Connolly M, Lewis A, Garfield BE, Natanek SA, Bloch S, Mouly V, Griffiths MJ, Polkey MI, Kemp PR. Garros RF, et al. Am J Respir Crit Care Med. 2017 Dec 1;196(11):1422-1433. doi: 10.1164/rccm.201701-0101OC. Am J Respir Crit Care Med. 2017. PMID: 28809518 Free PMC article.
OBJECTIVES: To identify microRNAs (miRNAs) that were increased in the quadriceps of patients with muscle wasting and to determine the molecular pathways by which they contributed to muscle dysfunction. ...In patients undergoing aortic surgery, preoperative levels of …
OBJECTIVES: To identify microRNAs (miRNAs) that were increased in the quadriceps of patients with muscle wasting and to determine the …
Eugenol attenuates ischemia-mediated oxidative stress in cardiomyocytes via acetylation of histone at H3K27.
Randhawa PK, Rajakumar A, Futuro de Lima IB, Gupta MK. Randhawa PK, et al. Free Radic Biol Med. 2023 Jan;194:326-336. doi: 10.1016/j.freeradbiomed.2022.12.007. Epub 2022 Dec 13. Free Radic Biol Med. 2023. PMID: 36526244 Free PMC article.
Further, we found that eugenol regulates the expression of HMGN1, CD151 and Ppp2ca genes during ischemia. Furthermore, we found that eugenol might protect the cells from ischemia through modulation of HMGN1 protein expression, which plays an active role in regulation of hi …
Further, we found that eugenol regulates the expression of HMGN1, CD151 and Ppp2ca genes during ischemia. Furthermore, we found that …
FOSL2 Is Involved in the Regulation of Glycogen Content in Chicken Breast Muscle Tissue.
Liu X, Liu L, Wang J, Cui H, Zhao G, Wen J. Liu X, et al. Front Physiol. 2021 Jul 6;12:682441. doi: 10.3389/fphys.2021.682441. eCollection 2021. Front Physiol. 2021. PMID: 34295261 Free PMC article.
The glycogen content in muscle of livestock and poultry animals affects the homeostasis of their body, growth performance, and meat quality after slaughter. ...Additionally, WGCNA revealed that FOSL2, CEBPB, MAP3K14, SLC2A14, PPP2CA, SLC38A2, PPP2R5E, and other gene …
The glycogen content in muscle of livestock and poultry animals affects the homeostasis of their body, growth performance, and meat q …
Co-expression analysis provides important module and pathways of human dilated cardiomyopathy.
Xiao J, Li F, Yang Q, Zeng XF, Ke ZP. Xiao J, et al. J Cell Physiol. 2020 Jan;235(1):494-503. doi: 10.1002/jcp.28989. Epub 2019 Jun 24. J Cell Physiol. 2020. PMID: 31236962
In addition, PPI analysis revealed that the genes HSP90AA1, CTNNB1, MAPK1, GART, and PPP2CA owned the largest number of adjacency genes, unveiling that they may function importantly during the occurrence of DCM. ...
In addition, PPI analysis revealed that the genes HSP90AA1, CTNNB1, MAPK1, GART, and PPP2CA owned the largest number of adjacency gen …
The broad phenotypic spectrum of PPP2R1A-related neurodevelopmental disorders correlates with the degree of biochemical dysfunction.
Lenaerts L, Reynhout S, Verbinnen I, Laumonnier F, Toutain A, Bonnet-Brilhault F, Hoorne Y, Joss S, Chassevent AK, Smith-Hicks C, Loeys B, Joset P, Steindl K, Rauch A, Mehta SG, Chung WK, Devriendt K, Holder SE, Jewett T, Baldwin LM, Wilson WG, Towner S, Srivastava S, Johnson HF, Daumer-Haas C, Baethmann M, Ruiz A, Gabau E, Jain V, Varghese V, Al-Beshri A, Fulton S, Wechsberg O, Orenstein N, Prescott K, Childs AM, Faivre L, Moutton S, Sullivan JA, Shashi V, Koudijs SM, Heijligers M, Kivuva E, McTague A, Male A, van Ierland Y, Plecko B, Maystadt I, Hamid R, Hannig VL, Houge G, Janssens V. Lenaerts L, et al. Genet Med. 2021 Feb;23(2):352-362. doi: 10.1038/s41436-020-00981-2. Epub 2020 Oct 27. Genet Med. 2021. PMID: 33106617 Free PMC article.
PURPOSE: Neurodevelopmental disorders (NDD) caused by protein phosphatase 2A (PP2A) dysfunction have mainly been associated with de novo variants in PPP2R5D and PPP2CA, and more rarely in PPP2R1A. Here, we aimed to better understand the latter by characterizing 30 individu …
PURPOSE: Neurodevelopmental disorders (NDD) caused by protein phosphatase 2A (PP2A) dysfunction have mainly been associated with de novo var …
29 results